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45-16 Ramsey Road Shirley, NY 11967, USA

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RKI-1447 is a potent Rho-associated ROCK kinase inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. RKI-1447 suppresses the activation of ROCK substrates MLC-2 and MYPT1. https://www.bocsci.com/rki-1447-cas-1342278-01-6-item-462699.html

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