Thyroid Tumor Cells

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Description

FTC-133 was isolated from a lymph node metastasis of a follicular thyroid carcinoma. The morphology differs from flat polygonal to spindle formed cells. They retained differentiated thyrocyte function and thyrocyte responsiveness to thyrotropin and local active growth factors. Thyroglobulin immunoreactivity could be shown in the cytoplasm and EGF receptor immunoreactivity could be visualised on the cell membranes. Complex chromosomal changes were detected as well as a p53 mutation.

Organism: Homo sapiens, human
STR DNA Profile: Amelogenin: X
CSF1PO: 10
D13S317: 11
D16S539: 11
D5S818: 12
D7S820: 9,10
THO1: 9.3
TPOX: 9
vWA: 15,18
Karyotype: Complex chromosomal changes
Source: Thyroid (lymph node metastasis)
Culture Properties: adherent
Morphology: Polymorphic
Recommended Medium: DMEM/Ham's F12 + 10% h.i. FBS.
Quality Control: Tests for mycoplasma, bacteria and fungi were negative
Storage and Shipping: liquid nitrogen vapor phase
Disease: Thyroid gland follicular carcinoma
Application: Function of human thyroid and development of thyroid cancer.


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